This invention provides compounds of Formula I having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with amido piperazine derivatives. These compounds possess unique antiviral activity, whether used alone or in combination with other antivirals, antiinfectives, immunomodulators or HIV entry inhibitors. More particularly, the present invention relates to the treatment of HIV and AIDS. ##STR1## A is selected from the group consisting of C_1-6alkoxy, C_1-6alkyl, C_3-7cycloalkyl, phenyl, and heteroaryl; wherein said heteroaryl may be monocyclic or bicyclic and may be comprised of three to eleven atoms selected from the group consisting of C, N, NR⁹, O, and S, and wherein each ring of said phenyl and heteroaryl is optionally substituted with one to five same or different substituents selected from the group consisting of R¹⁹-R²³; W is O or —NH; T is ##STR2## Z¹ is CR¹ or N; Z² is CR² or N; Z³ is CR³ or N; Z⁴ is CR⁴ or N; Z⁵ is CR⁵ or N; Z⁶ is CR⁶ or N; Z⁷ is CR⁷ or N; Z⁸ is CR⁸ or N.