The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising mutations in a CLCN4 gene. Such transgenic mice are useful as models for disease and for identifying agents that modulate gene expression and gene function, and as potential treatments for various disease states and disease conditions.


< Transgenic mice containing SOCS-5 cytokine signalling suppressor gene disruptions

< Screening assay

> Method of insertion of an expandable intervertebral implant using a tool

> Method and apparatus for the treatment of the intervertebral disc annulus

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