A novel soybean cultivar, designated SO22215, is disclosed. The invention relates to the seeds of soybean cultivar SO22215, to the plants of soybean SO22215 and to methods for producing a soybean plant produced by crossing the cultivar SO22215 with itself or another soybean variety. The invention further relates to hybrid soybean seeds and plants produced by crossing the cultivar SO22215 with another soybean cultivar.