The invention provides a series of Gq protein variants that
functionally couple to sensory cell receptors such as taste GPCRs (TRs) and olfactory
GPCRs (ORs) in an overly promiscuous manner. According to the invention, the functional
coupling can be determined, for example, by measuring changes in intracellular
IP3, or calcium. In a particular embodiment, the Gq protein variants
can be expressed in mammalian cell lines or Xenopus oocytes, and then evaluated
using calcium fluorescence imaging and electrophysiological recording.