Apparatus and methods are provided for controlling pressurization of a body cavity by controlling the rate and magnitude of pressurization during insufflation and/or exsufflation. In one variation, a pump may be used to either draw suction or to pressurize a body cavity. The pump may be connected to a controller that controls one or more regulators and/or valves for regulating pressurization. The controller preferably is programmable to allow a medical practitioner to input and/or rapidly alter desired pressurization parameters. In another variation, one or more pumps may be provided to simultaneously and independently control pressurization of multiple body cavities, such as a patient's stomach and peritoneal cavity.