A knee brace includes an adaptable strapping mechanism for securing an upper portion of the brace to a user's thigh wherein the strapping mechanism automatically adjusts to underlying soft tissue motion during knee and leg movement. The strapping mechanism generally includes a topmost horizontal strap and a pair of lower crossing straps. The horizontal strap and the crossing straps alternately tighten and loosen during normal leg flexing and straightening so as to maintain a tight skeletal grip on the users leg while adapting to thigh muscle movement. The individual straps of the strapping mechanism are independently adjustable to accommodate any leg size or shape.