Compounds represented by the following structure (I) are disclosed:
##STR00001## as are methods for making such compounds, wherein said
methods comprise reacting a diacyldiketopiperazine with a first aldehyde
to produce an intermediate compound; and reacting the intermediate
compound with a second aldehyde to produce the class of compounds with
the generic structure, where the first aldehyde and the second aldehydes
are selected from the group consisting of an oxazolecarboxaldeyhyde,
imidazolecarboxaldehyde, a benzaldehyde, imidazolecarboxaldehyde
derivatives, and benzaldehyde derivatives, thereby forming the above
compound wherein R.sub.1, R.sub.1', R.sub.1'', R.sub.2, R.sub.3, R.sub.4,
R.sub.5, and R.sub.6, X.sub.1 and X.sub.2, Y, Z, Z.sub.1, Z.sub.2,
Z.sub.3, and Z.sub.4 may each be separately defined in a manner
consistent with the accompanying description. Compositions and methods
for treating cancer and fungal infection are also disclosed.