The present invention discloses an ultrasound imaging system and method based on simultaneous multiple transmit-focusing using the weighted orthogonal chirp signals so that resolution of an ultrasound image is enhanced without sacrifice in the frame rate. The ultrasound imaging system according to the present invention includes: a storing means for storing weighted orthogonal signals including N number of orthogonal codes wherein the orthogonal codes are orthogonal to each other; a transmitter for transmitting simultaneously the weighted orthogonal signals as ultrasound transmission signals to corresponding N number of focal points within the target object; a receiver for receiving signals reflected from the N number of focal points corresponding to the transmitted ultrasound signals; a pulse-compressor for pulse-compressing with respect to each orthogonal code by extracting the stored N number of orthogonal codes from the reflected signals; a producer for producing receive-focused signals from the pulse-compressed signals; and a display for displaying the receive-focused signals by processing them. As a result, transmission signals are simultaneously transmitted to the plurality of focal points and received signals are separated on reception, thereby improving resolution without sacrifice in the frame rate.