A dental hygiene system provided with interchangeable dental heads permits power-enhanced brushing and concurrent fluid irrigation to optimize a user's personal dental hygiene efforts. The system has a handle assembly with an irrigation nozzle in close proximity to displaceable bristles driven by a battery-operated handle motor. Pumping of irrigation fluid such as an antiseptic solution into the oral cavity is also motor driven. A telescoping chamber with irrigation fluid fits on the piston-like base end of the handle and is refilled by docking the handle assembly on a complementary docking station that includes a detachable fluid reservoir, microswitch controls and a base fluid pump. Docking of the handle assembly triggers the microswitches and opens a check valve in the bottom of the handle chamber, which activates the flow of fluid from the reservoir into the chamber. An optional fiberoptic subassembly illuminates the oral cavity.