System and methods for predicting and dynamically adapting the most appropriate content and teaching strategies that aid individual student learning. System and methods are based on a cognitive model that integrates new information with what the student already knows. A program of study is predicted by the unique cognitive needs of the individual student correlated with aggregated student data history using an Artificial Intelligence Engine (AI Engine). Said system and methods then dynamically adapt the initial cognitive model to the student's ongoing progress using personalized software Agents. Said system and methods include a computer network that incorporates a server-side AI Engine and a collection of client-side software Agents embodied as animated characters. The program connects new information to prior knowledge and then strengthens these connections through dedicated learning Activities, customized to the student, to ensure that effective, and real, learning occurs.