A computer-based information handling system comprises a processor for executing an application program, audio output device, and video display device including a display screen for displaying a word in a language for audible playback. A pointing device controls a cursor movable on the display screen in response to a user operating the pointing device. A memory is provided for storing a digital recording of the word for audible playback and a rollover region is associated with the word for playback, defined at a position on the display screen overlapping a position of said word for playback on the display screen. The rollover region is configured to cause audible playback of the word in the on-screen language when at least a portion of the cursor is moved over the rollover region. In further aspects, a method, computer-readable medium, language instruction system, markup language document, and method for developing a language instruction system are also provided.