The invention relates to novel proteins with TNF-.alpha. antagonist activity and nucleic acids encoding these proteins. The invention further relates to the use of the novel proteins in the treatment of TNF-.alpha. related disorders, such as rheumatoid arthritis.

 
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< Uracil derivatives as inhibitors of TNF-.alpha. converting enzyme (TACE) and matrix metalloproteinases

< 5-pyridyl-1,3-azole compounds, process for producing the same and use thereof

> TNF-.alpha. binding molecules

> Hydantoin derivatives as inhibitors of matrix metalloproteinases and/or TNF-.alpha. converting enzyme
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