This invention provides nucleic acid sequences and characterization of the gene cluster responsible for the biosynthesis of the enediyne C-1027 (produced by Streptomyces globisporus). The pathway comprises a nonriobsomal peptide synthetase (NRPS). Methods are provided for the biosynthesis of enediynes, enediyne analogs and other biological molecules.

 
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< .beta.-secretase enzyme compositions and methods

< Transformant producing secondary metabolite modified with functional group and novel biosynthesis genes

> Compositions and methods of using apoptosis signaling kinase related kinase (ASKRK)

> Display of receptors and analysis of binding interactions and drug libraries
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