The present invention relates to peptides, particularly human monoclonal antibodies, that bind specifically to P. aeruginosa mucoid exopolysaccharide. The invention further provides methods for using these peptides in the diagnosis, prophylaxis and therapy of P. aeruginosa infection and related disorders (e.g., cystic fibrosis). Some antibodies of the invention enhance opsonophagocytic killing of multiple mucoid strains of P. aeruginosa. Compositions of these peptides, including pharmaceutical compositions, are also provided, as are functionally equivalent variants of such peptides.

 
Web www.patentalert.com

< Human kininogen D3 domain polypeptide as an anti-angiogenic and anti-tumor agent

< Method and composition for preventing or reducing the symptoms of insulin resistance syndrome

> Tri(alkylcarboxylato)gallium (III) products and pharmaceutical compositions containing them

> Antimicrobial solution for both tropical and oral use

~ 00293