A surgical instrument that is operable to deploy an anastomotic ring device comprises a proximal portion and a distal portion. The distal portion comprises a ring deployment mechanism, which is configured to receive and deploy an anastomotic ring. The proximal portion comprises a mechanism that is operable to remotely actuate the ring deployment mechanism. The distal portion is removable from the proximal portion. The distal portion may be selectively engaged with the proximal portion by a series of annular flanges and clamp arms that are configured to engage the annular flanges. The ability to remove the distal portion of the instrument permits the replacement of the ring deployment mechanism without requiring the replacement of the instrument in its entirety.