The present invention discloses a method for applying a multi-protocol label switching (MPLS) network in general packet radio service (GPRS). The MPLS network is established by multiple differentiated service (DS) domains. Each DS domain is constructed by multiple label switching routers (LSRs) and label edge routers (LERs). The LER provides at least a service GPRS supporting node (SGSN) connected to a wireless network base station, and a gate GPRS supporting node (GGSN) connected to a packet switching network. At a signalling plane, IP addresses of all SGSNs and GGSNs are utilized to establish all one-to-one pre-created label switching paths (LSPs) in the MPLS network of the GPRS backbone network. At a transmission plane, the pre-created LSP and LSP tunneling transmit packets between SGSN and GGSN.