Methods and systems for image overlap correction are provided. The method includes acquiring the emission projection data from a plurality of scan frames that extend across at least a portion of a length of an object being imaged wherein elements of the object lie between a region of overlap between two successive frames. The method further includes iteratively reconstructing a 3D image volume from multi-frame emission projection data by updating an estimate of 3D image volume using emission projection data from the plurality of frames within an iterative reconstruction loop.