This invention relates to compounds, which are generally anti-inflammatory and analgesic compounds, and which are represented by Formula I: ##STR00001## wherein A is a CH.sub.2, CH(OH), C(O), C.dbd.NOR.sup.4, NR.sup.5, O, S, S(O), or S(O).sub.2, and the other substituents are as defined in the specification; or prodrugs, individual isomers, mixtures of isomers, and pharmaceutically acceptable salts thereof. The invention further relates to pharmaceutical compositions containing such compounds and methods for their use as therapeutic agents.