An iontophoresis device includes an active electrode element operable to provide an electrical potential; an electrolyte reservoir comprising an electrolyte composition; an inner active agent reservoir comprising a gel matrix and distributed in said gel matrix, a first positively charged active agent; an inner ion selective membrane deposed between said electrolyte reservoir and said inner active agent reservoir; and an outermost ion selective membrane having an outer surface, the outer surface being against the biological interface, wherein, the gel matrix comprises a hydrophilic polycarboxylated polymer having net negative charges.