An iontophoresis device operable to deliver active agent to a biological interface such as skin or mucous membranes includes the combination of a hydrogel-based wound covering with an iontophoresis device to deliver antibiotic to biological interfaces. The effective concentration of antibiotics from oral or intravenous administration rarely reaches poorly perfused tissues such as cartilage or skin ulcerations resulting in entrenched and difficult to treat infections. Local deliver of additional antibiotic would serve to maintain the effective concentration of drug to the target tissues. Combining an iontophoresis device with a hydrogel-based wound covering to deliver localized antibiotic allows faster wound healing and prevent infection.