In the method, a set of limits applicable to a test rod pattern design are defined, and a sequence strategy for positioning one or more subsets of the test rod pattern design is established. Reactor operation on a subset of the test rod pattern design, which may be a subset of fuel bundles in a reactor core for example, is simulated to produce a plurality of simulated results. The simulated results are compared against the limits, and data from the comparison is provided to indicate whether any of the limits were violated by the test rod pattern design during the simulation. A designer or engineer may use the data to determine which operator parameters need to be adjusted (e.g., control blade notch positions for example) in order to create a derivative rod pattern design for simulation, and eventually perfect a rod pattern design for a particular core.