A compound of the formula (I); wherein the variables X.sub.1 to X.sub.10, R.sup.1 to R.sup.7 including R.sup.3', E, W, v, y, z, A and B are as described, or a pharmaceutically acceptable salt, solvate, enantiomer, racemate, diastereomer or mixtures thereof, useful for the treatment, prevention or amelioration of obesity and Related Diseases is disclosed.