Compositions including a degreaser, a dispersant, a fatliquor (for example a combination of sulfited synthetic spermwhale oil, neatsfoot oil, and coconut oil), and optionally Myrtaceae oil (for example the oil from a plant in the Melaleuca genera, such as Melaleuca alternifolia), and lanolin are disclosed. Such compositions are used to clean and condition any article, but in particular are used to clean and condition animal skins, such as sheepskin, or animal hairs, such as sheep's wool, and products made therefrom. In some examples, such compositions have an anti-microbial effect imparted by at least one component having anti-microbial properties. Such compositions can increase retention of the anti-microbial component(s) in a cleaned article, even under high-temperature washing conditions. These compositions are effective to clean and/or condition animal hairs, such as wool, and products containing animal hairs while leaving the cleaned article soft to the touch.