A method and system to manage the operation of multiple item promotions which provide a benefit to a customer who purchases a specified combination of items. The present invention monitors purchases in conjunction with Point Of Sale (POS) processing in a retail store and determines when purchase combination promotions are satisfied by a customer's purchase selections. The present invention stores a description of the items purchased in conjunction with the promotion, stores the cost of the promotion to be charged to each sponsor for each benefit or discount provided, and tracks future redemption of coupons or paperless equivalents that were issued in conjunction with a purchase combination promotion.