The oral administration to genetically alcoholic rats (from the strain
UChB of the University of Chile) of a compound selected from endogenic
polyamines (putrescine, spermidine, spermine), 1,3-propanediamine, their
pharmaceutically acceptable salts and solvates, and their bioprecursor
amides, causes a significant reduction in the alcohol consumption. The
activity lasts for some time after the treatment period. Besides, there
is a virtually null disulfiram-like adverse effect, what constitutes an
advantage over the unpleasant use of some anti-alcoholism agents, such as
calcium cyanamide or disulfiram itself. Therefore, the compounds of the
invention are useful for the preparation of medicaments for the
therapeutic and/or prophylactic treatment of alcoholism in human beings.