The present invention discloses a ground fault detection system and method for an inverter. The ground fault detection method for the inverter includes a reference value setting step for setting a reference value for estimating a ground fault current and a reference value for deciding a ground fault, a ground fault current estimation step for comparing a current value obtained by adding up current values flowing through each phase of an output terminal of the inverter with the reference value for estimating the ground fault current, and estimating generation of the ground fault current when the calculated current value is larger than the reference value, and a ground fault phase decision step for deciding the phase in which the ground fault has been generated on the basis of a current difference value between start and end points of 0 vector sections of each phase or between start and end points of 7 vector sections of each phase. Therefore, even if the ground fault occurs in an output line during the load operation or a power frequency of the inverter is similar to an output frequency, the ground fault detection system and method for the inverter detect the ground fault to improve operational reliability of the inverter.