Systems and methods are described for asymmetrically placed cross-coupled scintillation crystals. A method includes coupling a plurality of photomultiplier tubes to a scintillation crystal array, the scintillation crystal array defining a plurality of corner edges, wherein a first corner edge of the plurality of corner edges is aligned with a first center of a first photomultiplier tube of the plurality of photomultiplier tubes and a second corner edge of the plurality of corner edges is not aligned with a second center of a second photomultiplier tube of the plurality of photomultiplier tubes.