A system and method for managing healthcare in which payers, providers, pharmacists, and/or patients can interact with appropriate aspects of a particular treatment or surveillance plan. Treatment and/or surveillance plans can be designed, created, selected, implemented, tracked, evaluated, modified, improved, expanded, and/or otherwise managed. Outcomes data can be used to update efficacy data, which in turn can influence future treatment and/or surveillance plans. A wide variety of different types of data can influence the functionality of the system. A wide range of technical architectures can be used to achieve the functionality of the system.