This invention relates to novel tetrazole and oxadiazalone .beta.-amino acids derivatives of the formula ##STR00001## wherein G is ##STR00002## wherein R.sup.1 through R.sup.4 are defined as in the specification, pharmaceutical compositions containing them and their use for the treatment of various central nervous system and other disorders. The cyclopropyl .beta.-amino acids derivatives of this invention exhibit activity as alpha2delta ligands (.alpha.2.delta. ligands). Such compounds have affinity for the .alpha.2.delta. subunit of a calcium channel.