A system for improving patient compliance with a prescription drug regimen is described. The system includes a patient database for storing patient information, the information including contact information for a patient communication device (such as a telephone, cell phone, computer, or PDA) along with a method for communicating with that device. The system further includes an alert database for storing information about prescription reminder alerts to be sent to patients. A send program running on a computer retrieves information about prescription reminder alerts from the alert database and transmits the prescription reminder alerts to a patient communications device over a communications network using the contact information and contact method stored in the patient database.