Disclosed are polymeric compounds which are useful as prodrugs, comprising
a chain of monomeric nucleosides, nucleoside analogs or abasic
nucleosides, wherein at least one of the nucleosides or nucleoside
analogs or a heterocyclic derivative thereof is pharmaceutically active
and the nucleosides, nucleoside analogs or abasic nucleosides are linked
by a phosphodiester group, a phosphorothioate group or an H--, alkyl or
alkenyl phosphonate group.