The present invention relates to compounds with the formula (I), (II), (III) or (IV): ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, X and Z are as defined herein, and also to pharmaceutical compositions comprising the compounds, as well as methods of use of the compounds for treatment of disorders associated with human 11-.beta.-hydroxysteroid dehydrogenase type 1 enzyme and for the preparation of a medicament which acts on the human 11-.beta.-hydroxysteroid dehydrogenase type 1 enzyme.