The present disclosure relates to an implant for insertion into a tissue defect, such as a cartilage defect or a cartilage and bone defect. The implant includes a plug including a porous polymeric material having at least one channel therein, wherein the plug is sized to fit the tissue defect; and tissue. The tissue substantially fills the channel and is selected from a group including autologous tissue, allogenic tissue, cultured tissue, or combinations thereof. In an embodiment, the plug includes a plurality of porous polymeric phases. In another embodiment, the plug includes a plurality of channels wherein the channels are longitudinal and/or transverse. A method for repairing defective tissue is also disclosed.


> Computer systems and methods for identifying surrogate markers

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