The invention provides surgical needles with a porous distal portion from
which a liquid injectate will weep or ooze multidirectionally under
injection pressure while the porous distal portion of the needle is
inserted into a body surface. The porous distal portion of the needle can
be fabricated from a porous carbon, metal, ceramic or polymer and
preferably has a decreasing gradient of impedance to fluid flowing to the
point of the needle to compensate for the falling off of injection
pressure as fluid moves towards the point, thereby ensuring uniform
weeping of the injectate along the injection course. The needle is
adapted for attachment to a catheter or syringe. In another embodiment, a
surgical assemblage is provided wherein a porous distal portion having
similar fluid flow characteristics is located along the distal end of a
catheter, and a needle point is attached to the distal end of the
catheter (e.g., a steerable catheter) for piercing tissue. A guidance
catheter can be used to direct the invention devices to a remote internal
injection site. The invention devices and methods can be used to inject
fluids (including those containing nucleic acids for gene therapy) into
interior body walls or tissue, such as a beating heart, without
substantial loss of fluid and without substantial damage to tissue caused
by injectate.