A system and method for interconnecting two network domains operable to transport SS7 traffic of different types. A gateway disposed between a first network domain and a second network domain includes a generic Interworking functionality that is operable to effectuate an MTP2-based relay linkage between a first MTP2 interface and a second MTP2 interface. A first link segment is established between the gateway's first MTP2 interface and an equivalent interface in the first network domain's end node. A second link segment is established between the gateway's second MTP2 interface and a corresponding equivalent interface in the second network domain's end node. Thereafter, the relay linkage coupling the link segments is established for facilitating MTP2 traffic therebetween.