A chemiresistor sensor system that compensates for changes in resistance caused by changes in ambient temperature, thereby increasing the accuracy of the sensor system's ability to detect target analytes. The sensor system generally includes a first resistor, a second resistor, and a load regulator or switch that is sensitive to changes in ambient temperature. At least one of the first resistor and the second resistor is a sensing element having a resistance that changes in response to the presence of one or more of the analytes. The switch manages an electrical load across the first resistor and the second resistor. The switch prevents passage of the electrical load across the first and/or second resistor when the ambient temperature is at a first value. The switch permits passage of the electrical load across the first and/or second resistor when the ambient temperature is at a second value.