A method of digital image combination for multiple channels with multiple sets and a bus interface which includes an image-processing unit for m-channel sub-images, an image-processing unit for n-set combining images, n-set video data buses, address and control buses and a pixel data access control and bus switching logic module. A bus strobe signal controls m-channel sub-images pixel data outputting to one set of the n video data buses at a specific moment. The n sets of image-processing units for combining images combine the sub-images pixel data on the video data buses of n sets to form n integral image data. The method can be used in the multimedia image communication system and image editing system for raising the multiple image-processing capabilities.