A microinfusion device, comprising: (a) a subcutaneously implantable reservoir configured to contain a drug, the reservoir being mountable within a burr hole of a skull of a subject; (b) a dose control system configured to control flow of the drug; and (c) a microcatheter configured to deliver the drug from the reservoir to a target location. Another embodiment provides a microinfusion device, comprising: a subcutaneously implantable reservoir configured to contain a drug, the implantable reservoir having at least two outlets. A further embodiment provides a microinfusion device, comprising: (a) a subcutaneously implantable reservoir configured to contain a drug, the reservoir being mountable within a burr hole in a skull of a patient, the reservoir being ring-shaped; and (b) a microcatheter configured to deliver the drug from the reservoir to a target location. Yet another embodiment provides a microinfusion device, comprising: (a) a subcutaneously implantable reservoir having septations configured to separate different drugs within the reservoir; and (b) at least one microcatheter configured to deliver the different drugs from the reservoir to at least one target location.