Method and system for multiple volume exploration is disclosed. A first 3D volume is rendered in a first region. One or representations are displayed in a second region, where each representation signifies a stack of 2D images. A first stack represents one or more 2D images of cross sections of a certain orientation from the first 3D volume. Each of the other stacks includes one or more 2D images of cross sections of the same orientation from a 3D volume related to the first 3D volume.