A device which combines pneumatic compression therapy and ultrasound based therapy for the prevention and treatment of thrombosis. Ultrasound transducers (11) are placed in specially designed pockets (12) in stockings (23) or leggings (25). This allows for convenient use of ultrasound therapy. Pneumatic compression is also carried out by air bladders (14) which are placed in leggings. The overall result is an easy to use device which should produce significantly better results in the prevention and treatment of thrombosis, ultimately reducing patient morbidity and mortality.