This invention is directed to physiologically active compounds of formula (I) ##STR00001## wherein ##STR00002## represents a bicyclic ring system, of about 10 to about 13 ring members, in which the ring ##STR00003## is an azaheterocycle, and the ring ##STR00004## represents an azaheteroaryl ring, or an optionally halo substituted benzene ring; and N-oxides thereof, and pharmaceutically acceptable salts of the compounds of formula (I) and N-oxides thereof,Such compounds inhibit the production or physiological effects of TNF and inhibit cyclic AMP phosphodiesterase. The invention is also directed to pharmnaceutical compositions comprising compoundS of formula (I), their phatmaceUtical use and methods for their preparation.