The present invention provides a compound of formula (I): in which Ar and R.sup.1 are phenyl or a heteroaromatic group, R.sup.2 is generally hydrogen, R.sup.3 is hydrogen or alkyl and X, Y and Z are generally CH or N as VR-1 antagonists; or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising it; its use in therapy; use of it to manufacture medicaments to treat pain or inflammation; and methods of treating pain or inflammation ##STR00001##