In a biopsy system having a biopsy needle guide secured to a needle guide support bracket, a biopsy needle guide is provided that includes a body having a periphery that defines an edge of the needle guide, the periphery defining a top surface, a bottom surface and a pair of side surfaces. A cradling aperture is positioned in the body and sized to engage the needle guide support bracket. A channel is provided in communication with the cradling aperture. The channel extends inwardly from one of the side surfaces of the body toward the cradling aperture. The needle guide of the present invention inhibits movement of the needle guide relative to the support bracket during a biopsy procedure.