The present invention discloses a single-channel comprehensive protection circuit of a self-excitation half-bridge series resonant circuit having a single lamp output, including a DC block capacitor C.sub.3, a first partial pressure resistor R.sub.1, a second partial pressure resistor R.sub.2, a rectifying diode D.sub.1, a filter and integral capacitor C.sub.4, a release resistor R.sub.3, a diac D.sub.2, a filter capacitor C.sub.5, a filter resistor R.sub.4, wherein the method of one point of loading point A at the fluorescent lamp filament is used. The present invention normalizes the treatment of abnormal signals for over-current, over-voltage and end of lamp life state etc. in order to replace the conventional design of multi-channel and multi-point sampling for simplifying the circuit, reducing the cost and space, increasing reliability, and facilitating miniaturization development of the electronic lighting products. The present invention can be applied in the self-excitation half-bridge series resonant circuit of a single-lamp, the self-excitation half-bridge series resonant circuit of the multi-lamps, the separate-excitation half-bridge series resonant circuit of a single-lamp and the separate-excitation half-bridge series resonant circuit of the multi-lamp.