A method and system of multi-channel echo cancellation using round robin regularization. The multi-channel round robin regularization echo cancellation method includes applying a plurality of adaptive filters, each having an inverse correlation matrix, to the multi-channel playback signal. Each of the plurality of adaptive filters is selected in a round robin sequence, so that every round each of the filters is selected. The inverse correlation matrix associated with each selected adaptive filter then is regularized as needed. The regularized adaptive filter then is used to remove the echo of the multi-channel playback signal from a captured signal. Regularization is implemented in a round robin manner to ensure that each subband is selected so that the adaptive filter for that subband can be examined. Other features of the multi-channel echo cancellation system and method include dynamic switching between monaural and multi-channel echo cancellation and mixed processing for lower and upper subbands.