A method for providing maximum likelihood detection with decision feedback interference cancellation is provided. The method includes estimating a current symbol with previous symbol interference (PSI) removed based on estimated previous symbols. A next symbol is estimated with PSI removed based on the estimated current symbol and/or the estimated previous symbols. The current symbol is re-estimated with PSI removed based on the estimated previous symbols and next symbol interference (NSI) removed based on the estimated next symbol. This method of providing maximum likelihood detection with decision feedback interference cancellation may be used in direct sequence spread spectrum systems with relatively short block spreading, such as IEEE802.11b Wireless LAN standard, or in any other suitable systems.