A system and method for prescription therapy management and compliance are provided. The system framework integrates primary databases from pharmacies, pharmacy benefit managers (PBMs), health plans, and EHR providers with a secondary database system, user interface, and wireless messaging platform, in order to extract and aggregate user-specific prescription data and make it available to users through a personalized account and as a part of a wireless prescription reminder service. The system helps users access, aggregate, manage, update, automate, and schedule the prescriptions they are currently taking. Users receive real-time wireless prescription dosing reminders based on their prescribed drug, dosage, and other indications, tailored to each individual's daily schedule. These wireless dosing reminders (i) include additional instructional content such as pill images, compliance tools, and Web or WAP drug links, (ii) are automatically scheduled and transmitted based on the user's prescription source data, in conjunction with selections indicated on their personal account, and (iii) are transmitted via SMS, EMS, MMS, WAP, email, and other formats to the user's mobile phone, PDA, or other wireless device. The integrated interface and secondary database system enable a number of additional system features which focus on compliance and management of the underlying source prescription data.