The invention concerns a method for preparing compounds for interaction of
an active substance hardly soluble in an aqueous medium with a porous
support. The invention is characterized in that it comprises the
following steps: (a) mixing the active substance generated by
supercritical fluid and the specific amount of porous support; (b)
carrying out a molecular diffusion step by contacting in static mode a
supercritical fluid with the mixture obtained at step (a) for the time
required to improve the dissolution in the aqueous medium of the mixture
obtained at step (a); (c) washing the interactive compound obtained at
step (b) with a supercritical fluid flow; (d) recuperating the particles
of the interactive compound thus formed. The invention also concerns a
compound obtainable by said method.