In a method of operating a 4-stroke internal combustion engine selectively in a compression ignition operation, in which an outlet valve of the internal combustion engine is closed at a comparatively early closing time point with respect to a crank angle (.alpha.) and in spark ignition operation, in which the outlet valve is closed at a comparatively late closing time point with respect to the crank angle (.alpha.), during the changeover from the spark ignition mode of operation to the compression ignition mode of operation, the closing time point of the outlet valve is transferred from the late closing time point to the early closing time point in steps distributed over multiple 4-stroke cycles.