System and methods for optimizing communications between an RFID reader and a population of tags are described. To minimize the amount of data exchanges, the reader and tags use non-sequential bit string or byte masking. In non-sequential bit string masking, the reader transmits an interrogation mask having a plurality of non-sequential sub-masks to the tags. During subsequent collection of the identification sequence, the reader and tags only exchange the non-masked bit positions. The interrogation mask can be determined using superposition processing, historical tendencies, or known identification and/or subset of identification ranges. During superposition processing, the reader determines whether a bit position contains a single value or multiple values for tags in the tag population. If the bit position contains a single value, the bit position is designated as masked. If the bit position contains multiple values, the bit position is designated as non-masked.